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Amaryl (Glimepiride)
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Amaryl

Generic Amaryl is the medication of high quality, which is taken in treatment of type 2 diabetes. Generic Amaryl is acting by stimulating the pancreas to produce more insulin. It is sulfonylureas.

Other names for this medication:
Adglim, Adinsulin, Adiuvan, Amadiab, Amadin, Amagen, Amarel, Amarine, Amarwin, Amarylle, Amyline, Amyx, Anpiride, Apo-glim, Apo-glimep, Apo-glimepiride, Aramil, Asoride, Avaglim, Avandaglim, Avandaryl, Avaron, Aylide, Azulix, Betaglid, Betaglim, Co glimepiride, Dactus, Dia-ban, Diabirel, Diaglim, Diaglime, Diaglin, Dialon, Dialosa, Diameprid, Diamitus, Diapride, Diaril, Diaryl, Dimavyl, Dimirel, Eglymad, Endial, Euglim, Friladar, Gemer, Getryl, Glamarol, Glamaryl, Glemaz, Glemep, Glemid, Glempid, Glibetic, Glibezid, Glidiamid, Glimaryl, Glimax, Glimcare, Glime-q, Glimed, Glimedoc, Glimegamma, Glimehexal, Glimepibal, Glimepil, Glimepirid, Glimepirida, Glimepiridum, Glimepiron, Glimeprid, Glimerax, Glimerid, Glimeride, Glimeryl, Glimesan, Glimespes, Glimestad, Glimestada, Glimewin, Glimex, Glimexal, Glimexin, Glimide, Glimirid, Glimosa, Glims, Glimulin, Glincil, Glindia, Gliper, Gliperid, Gliperin, Glipid, Glipiren, Glipiride, Gliprex, Glirid, Gliride, Glitra, Glix, Gluceride, Glucomet, Gluconor, Gluconorm, Glucopirid, Glucopirida, Glucoryl, Glupropan, Glutim, Gluvas, Glycemager, Glypride, Grexa, Grumed, Idesal, Imerid, Irys, Islopir, Lavida, Limeral, Limpet, Lomet, Losucon, Magna, Mapryl, Meglimid, Melyd, Mepid, Mepirid, Merck-glimepiride, Metis, Metrix, Monorel, Norizec, Oltar, Paride, Ratio-glimepiride, Relide, Roname, Sanprid, Secrin, Sintecal, Solosa, Stimulin, Symglic, Trical

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Also known as:  Glimepiride.

Description

Generic Amaryl is the medication of high quality, which is taken in treatment of type 2 diabetes.

The target of this perfect remedy is struggle against type 2 diabetes.

Amaryl is also known as Glimepiride, Diapride, Amyline, Euglim.

Generic Amaryl is acting by stimulating the pancreas to produce more insulin. It is sulfonylureas.

Generic name of Generic Amaryl is Glimepiride.

Brand name of Generic Amaryl is Amaryl.

Dosage

Take Generic Amaryl tablets orally with breakfast or the first big meal of the day.

Do not crush or chew it.

Take Generic Amaryl at the same time once a day with water.

If you want to achieve most effective results do not stop taking Generic Amaryl suddenly.

Overdose

If you overdose Generic Amaryl and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amaryl are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Amaryl if you are allergic to Generic Amaryl components.

Do not take Generic Amaryl if you're pregnant or you plan to have a baby, or you are a nursing mother. Generic Amaryl can ham your baby.

It can be dangerous to use Generic Amaryl if you suffer from or have a history of heart disease.

Avoid alcohol.

Do not stop taking Generic Amaryl suddenly.

amaryl dosage

The hypoglycemic sulfonylurea drugs cause reduction of blood glucose predominantly via stimulation of insulin release from pancreatic beta cells. In addition, during long-term treatment, an insulin-independent blood glucose-decreasing mechanism is assumed to operate. This may include insulin-sensitizing and insulin-mimetic activity in muscle and adipose tissue. This review summarizes our current knowledge about the putative modes of action of the sulfonylurea compound, Amaryl, in pancreatic beta cells and, in particular, peripheral target cells that form the molecular basis for its characteristic pharmacological and clinical profile. The analysis was performed in comparison with the conventional and the "golden standard" sulfonylurea, glibenclamide. I conclude: (I) The blood glucose decrease provoked by Amaryl can be explained by a combination of stimulation of insulin release from the pancreas and direct enhancement, as well as potentiation of the insulin response of glucose utilization in peripheral tissues only. (II) The underlying molecular mechanisms seemed to rely on beta cells on a sulfonylurea receptor protein, SURX, associated with the ATP-sensitive potassium channel (K(ATP)) and different from SUR1 for glibenclamide, and in muscle and adipose cells on: (a) the increased production of diacylglycerol and activation of protein kinase C; (b) the enhanced expression of glucose transporter isoforms; and (c) the insulin receptor-independent activation of the insulin receptor substrate/phosphatidylinositol-3-kinase pathway. (III) The latter mechanism involved a nonreceptor tyrosine kinase and a number of components, such as caveolin and glycosylphosphatidylinositol structures, which are assembled in caveolae/detergent-insoluble glycolipid-enriched rafts of the target cell plasma membrane. Since hyperinsulinism and permanent K(ATP) closure are supposed to negatively affect the pathogenesis and therapy of non-insulin-dependent diabetes mellitus, the demonstrated higher insulin-independent blood glucose-lowering activity of Amaryl may be therapeutically relevant.

amaryl drug information

Twelve weeks of treatment resulted in a mean (sem) placebo-corrected lowering in HbA(1c) levels of 0.40% (± 0.14); 4.4 mmol/mol (± 1.5) for 1 mg linagliptin, 0.73% (± 0.14); 8.0 mmol/mol (± 1.5) for 5 mg, and 0.67% (± 0.14); 7.3 mmol/mol (± 1.5) for 10 mg. Differences between linagliptin and placebo were statistically significant for all doses (1 mg, P = 0.01; 5 mg and 10 mg, P < 0.0001). The change in mean (sem) placebo-corrected HbA(1c) from baseline was -0.90% (± 0.13); -9.8 mmol/mol (± 1.4) for glimepiride. Adjusted and placebo-corrected mean changes in fasting plasma glucose were -1.1 mmol/l for linagliptin 1 mg (P = 0.002), -1.9 mmol/l for 5 mg and -1.6 mmol/l for 10 mg (both P < 0.0001). One hundred and six (43.1%) patients reported adverse events; the incidence was similar across all five groups. There were no hypoglycaemic events for linagliptin or placebo, whereas three patients (5%) receiving glimepiride experienced hypoglycaemia.

amaryl 5 mg

The three dual therapies using a combination of metformin and either sulfonylurea, pioglitazone, or sitagliptin showed similar glycemic effectiveness among drug-naïve Korean T2D patients. In addition, these regimens were similarly effective across a wide range of baseline HbA1c levels.

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Overall, 19% of patients who received a sulfonylurea experienced at least one episode of hypoglycemia: 22% receiving glyburide, 19% receiving glimepiride, and 16% receiving glipizide. Variables included in the multivariate regression were age 65 years or older, glomerular filtration rate (GFR)≤ 30 ml/min/1.73 m(2) , and treatment with glipizide, glyburide, or concurrent intermediate- or long-acting insulin. Age 65 years or older (odds ratio [OR] 3.07, p < 0.001), intermediate- or long-acting insulin (OR 3.01, p=0.002), and GFR of 30 ml/minute/1.73 m(2) or lower (OR 3.64, p=0.006) were predictors of hypoglycemia. Cases were less likely than controls to receive glipizide (OR 0.44, p=0.005).

amaryl dose diabetes

In patients with type 2 diabetes inadequately controlled on metformin monotherapy, add-on glimepiride or pioglitazone results in similar overall improvements in glycemic control. Compared with pioglitazone, glimepiride is associated with faster glycemic control, lower total and LDL cholesterol levels and reduced short-term healthcare costs.

amaryl maximum dose

Between August, 2010, and June, 2011, 1549 patients were randomly assigned to receive empagliflozin (n=769) or glimepiride (n=780); four patients in the empagliflozin group did not receive the assigned treatment. Empagliflozin was non-inferior to glimepiride at both timepoints. At week 104, adjusted mean difference in change from baseline in HbA1c with empagliflozin versus glimepiride was -0·11% (95% CI -0·19 to -0·02; p=0·0153 for superiority). Adverse events were reported in 661 (86%) patients treated with empagliflozin and 673 (86%) patients treated with glimepiride. Severe adverse events were reported in 72 (9%) patients in the empagliflozin group and 68 (9%) in the glimepiride group. Serious adverse events were reported in 119 (16%) patients in the empagliflozin group and 89 (11%) in the glimepiride group. Confirmed hypoglycaemic adverse events (plasma glucose ≤3·9 mmol/L or requiring assistance) at week 104 were reported in 19 (2%) patients treated with empagliflozin and 189 (24%) patients treated with glimepiride.

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Dapagliflozin, an SGLT2 inhibitor, offers a novel treatment option for type 2 diabetes that is independent of insulin secretion or action.

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In patients with lower β-cell function, the addition of a sulfonylurea to a metformin regimen was associated with an increased risk for hypoglycemia compared with that in patients with higher β-cell function; low hypoglycemia event rates with the addition of saxagliptin limited equivalent assessments. These findings in older patients are especially relevant because morbidity associated with hypoglycemia is higher in this age group. ClinicalTrials.gov identifier: NCT01006603 (ClinicalTrials.gov).

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Testimonials
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amaryl generic 2016-02-05

To determine the effectiveness of triple oral antidiabetic therapy with a sulfonylurea, a biguanide, and a Cytoxan Drug Insert thiazolidinedione, we analyzed the results in 35 patients who had previously had inadequate glycemic control with a combination of glimepiride and metformin. The study cohort consisted of 27 men and 8 women (mean age, 55.8 years) who had had type 2 diabetes mellitus for a mean duration of 8.7 years. The addition of troglitazone (600 mg/day administered with the largest meal) to the glimepiride and metformin therapy yielded normal or near-normal glycemia in all 35 patients. Glycemic control was initially associated with mean weight gain; subsequently, however, mean weight was reduced to below the baseline level--perhaps attributable to the anorectic effect of metformin. Thus, for the first time, triple oral antidiabetic therapy with glimepiride, metformin, and troglitazone has been shown to be an efficacious therapeutic option for type 2 diabetes.

amaryl drug 2017-01-26

The study involved 50 consecutive outpatients (33 males and 17 females; mean age of 72.5±9.5 years) who visited our hospitals for a risk-screening test or treatment for T2DM. They underwent complete history and physical examination, and determination of blood chemistry and anthropometric variables, and then were randomized to receive either anagliptin (n=26) or glimepiride (n=24) Bystolic Dosage Amounts for 6 months.

amaryl generic name 2015-07-14

These data indicate Zanaflex 800 Mg that, among the array of signals, indirect reciprocal beta-cell-mediated signaling predominates over direct alpha-cell signaling in the regulation of glucagon secretion in humans.

amaryl tablets 2015-05-17

Significant reductions in HbA(1c) were observed within 8 weeks of treatment with liraglutide plus OADs (p < 0.0001) and Paxil 80 Mg maintained until week 26. Furthermore, liraglutide plus OADs led to significant reductions in FPG within 2 weeks (p < 0.0001) and sustained over 26 weeks. Adding liraglutide to metformin or metformin plus rosiglitazone also led to early reductions and maintained reductions in body weight (within 8 weeks, p < 0.0001); however, liraglutide treatment plus glimepiride was weight neutral. Rapid reductions in SBP were observed for liraglutide plus OADs (within 2 weeks, p < 0.05-0.001) and maintained for 26 weeks. Some patients experienced nausea, which for the majority it diminished within 2 weeks.

amaryl pills 2017-06-04

Knowledge of these polymorphisms provides no clinical useful Cocaine Viagra Alcohol information for the pharmacogenetic therapeutic approach for Korean patients with type 2 diabetes.

amaryl brand 2017-01-20

Primary cultured human white pre-adipocytes were differentiated in vitro according to a standard protocol. Lipid accumulation was assessed by Oil Red O staining and determination of triglyceride content; gene expression was measured by RT PCR Effexor Usual Dose and Western blotting.

amaryl oral medication 2016-01-07

The single nucleotide polymorphism rs10494366 in the nitric oxide synthase 1 adaptor protein (NOS1AP) gene Effexor Replacement Drug is associated with QTc prolongation, through an effect on the intracellular Ca levels. As sulfonylurea stimulate insulin secretion by an increased influx of Ca, we hypothesized that this polymorphism is associated with the glucose-lowering effect and mortality risk in sulfonylurea users.

amaryl overdose symptoms 2015-02-28

More patients treated with canagliflozin experienced reductions in both HbA1c and Flomax Capsule body weight compared with glimepiride for up to 104 weeks. Canagliflozin was generally well tolerated in patients with T2DM when used in combination with metformin.

amaryl drug card 2017-05-09

S.C. insulin Novolog Mix [70/30], pre-supper was initiated in 12 subjects on metformin, 14 subjects on glimepiride, and 12 subjects receiving both drugs, with HbA1C > 7.5% and eight subjects receiving placebo. Insulin dose was increased by 4 U at weekly interval until fasting blood sugar [FBS] between 6.6 and 8 mM/l was attained and then further titrated by 2 U every week to attain and maintain FBS between 4.5 and 6.7 mM/l over the next 4 months. The comparisons were conducted between these groups for HbA1C, the daily insulin dose, body weight noted at the end of this study period as well as the hypoglycemic episodes per patient during the last 4 weeks of the study period.

tablet amaryl 3mg 2017-03-18

Although it blocks sarcolemmal currents in rat cardiac myocytes, Glim does not block the beneficial effects of mitochondrial K(ATP) channel opening in the isolated rat heart. These data may have significant implications for the treatment of type 2 diabetes in patients with ongoing ischemic heart disease.

amaryl 86 mg 2016-08-20

Exenatide significantly reduced MG, SD, and MAGE, whereas glimepiride did not. Fasting glucose and glycated hemoglobin were lowered in both groups, even if the reduction was not significant.

amaryl 2mg tablets 2016-07-02

Canagliflozin 100 and 300 mg provided reductions in HbA1c, body weight, and systolic BP across studies in patients from Latin America that were generally similar to those seen in the overall populations of patients with T2DM. The AE profile in patients from Latin America was equivalent to that in the overall populations; higher rates of genital mycotic infections and osmotic diuresis-related AEs were seen with canagliflozin versus comparators. Limitations of this study include the post hoc analysis of data and the small sample size of patients from Latin America.