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Lamictal (Lamotrigine)
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Lamictal

Generic Lamictal is a single antiepileptic drug(AED) of the phenyltriazine class. Generic Lamictal is a medication indicated for adjunctive therapy for infancy with the following types of seizure: partial seizures, primary generalized tonic-clonic seizures, generalized seizures of Lennox-Gastaut syndrome; monotherapy for adult patients with partial seizures who are also receiving their treatment with carbamazepine, phenytoin, phenobarbital,primidone and valproate.

Other names for this medication:
Apo-lamotrigine, Arvind, Convulsan, Crisomet, Dafex, Daksol, Danoptin, Dezepil, Doclamotri, Dyna-lamotrigine, Elmendos, Epilepax, Epimil, Epiral, Epitec, Epitrigine, Epizol, Espa-trigin, Flamus, Fringanor, Gerolamic, Labileno, Lafigin, Lagotran, Lamal, Lambipol, Lamdra, Lamepil, Lameptil, Lametec, Lameton, Lamez, Lamia, Lamicstart, Lamictin, Lamidus, Lamilept, Lamirax, Lamitor, Lamitrin, Lamo tad, Lamo-q, Lamodex, Lamogin, Lamogine, Lamolep, Lamorin, Lamoro, Lamotax, Lamotaxyl, Lamotiran, Lamotor, Lamotren, Lamotri hexal, Lamotrig-isis, Lamotrigin, Lamotrigina, Lamotriginum, Lamotrihexal, Lamotrin-mepha, Lamotrix, Lamox, Laribax, Larig, Latrigil, Latrigin, Latrigine, Logem, Lomarin, Medotrigin, Meganox, Mogine, Neurium, Plexxo, Pms-lamotrigine, Protalgine, Ratio-lamotrigine, Sandoz lamotrigine, Seaze, Symla, Tradox, Trigila, Triginet, Triglyx, Trogine

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Also known as:  Lamotrigine.

Description

Generic Lamictal is a medication indicated for adjunctive therapy for infancy with the following types of seizure such as partial seizures, primary generalized tonic-clonic seizures, generalized seizures of Lennox-Gastaut syndrome; monotherapy for adult patients with partial seizures who are also receiving their treatment with carbamazepine, phenytoin, phenobarbital,primidone and valproate; bipolar disorder treatment for adults. Generic Lamictal helps to control mood episodes (depression, mania, hypomania and mixed episodes).

Generic Lamictal remains an effect of sodium channels. Generic Lamictal keeps off sodium channels thereby stabilizing nervous membranes and hereupon modulate presynaptic transmitter release of excitatory amino acids.

Lamictal is also known as Lamotrigine, Lametec.

Generic name of Generic Lamictal is Lamotrigine.

Brand name of Generic Lamictal is Lamictal.

Dosage

Take it orally.

Generic Lamictal can be used by children and adults.

If you want to achieve most effective results do not stop taking Generic Lamictal suddenly.

Overdose

If you overdose Generic Lamictal and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Generic Lamictal overdosage: ataxia, nystagmus, increased seizures, decreased level of consciousness, coma, intraventricular conduction delay.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Lamictal are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Generic Lamictal if you are allergic to Generic Lamictal components.

Be careful with Generic Lamictal if you are pregnant, planning to become pregnant, or are breast-feeding.

Be careful with Generic Lamictal in case of different types of contraception usage, hepatic impairment, renal impairment.

It can be dangerous to stop Generic Lamictal taking suddenly.

lamictal increased dosage

The availability of new antiepileptic drugs (AEDs) has expanded the spectrum of medical treatment options in epilepsy. However, the development of ten new compounds (vigabatrin, felbamate, gabapentin, lamotrigine, topiramate, tiagabine, oxcarbazepine, levetiracetam, zonisamide, and pregabalin) has not changed the basic principles of epilepsy treatment. The choice of an AED depends upon seizure type or seizure syndrome, efficacy, safety, tolerability, patient age and gender, concomitant medication, and comorbid conditions. In general, most of the newer AEDs are not necessarily more effective but usually better tolerated than the traditional agents mainly because of their favorable pharmacokinetic profiles and fewer drug interactions. Because treatment options have been widened with the introduction of these new compounds, drug therapy can now be tailored to the requirements of the individual patient. Nevertheless, significant safety and efficacy issues continue to exist and there is a strong need for the development of even better agents. This clinical review focuses on current aspects of drug therapy in epilepsy.

lamictal reviews anxiety

In this systematic review we present information relating to the effectiveness and safety of the following interventions: antidepressants, carbamazepine, chlorpromazine, clonazepam, cognitive therapy, education, family-focused psychoeducation, gabapentin, haloperidol, lamotrigine, lithium, olanzapine, psychological treatments, quetiapine, risperidone, topiramate, valproate, and ziprasidone.

lamictal reviews

Concomitant use of carbamazepine and indinavir may cause failure of antiretroviral therapy due to insufficient indinavir plasma concentrations. Drugs other than carbamazepine should be considered to prevent this interaction. Amitriptyline or gabapentin are alternatives for postherpetic neuralgia; valproic acid or lamotrigine are alternatives for seizures. When alternate drug therapy is not possible, dosage adjustments, therapeutic drug monitoring, and careful clinical observation may help reduce adverse clinical consequences.

700 mg lamictal

Lamotrigine (LTG) is an antiepileptic drug (AED) recently released in several countries. It is effective for a variety of seizure types in adults and children both as an add-on agent and in monotherapy, and is generally well tolerated. This report reviews the apparent risk factors for rash associated with LTG to determine whether and how the risk of serious rash can be minimized in practice.

lamictal medication bipolar

Four studies with a total of 145 participants were identified. Response rates were higher in patients treated with tranylcypromine (60.0%-80.7%; overall response rate, 73.7%) compared with placebo, imipramine, and lamotrigine (the latter as add-on to a mood stabilizer) (12.9%-47.6%; overall response rate, 27.5%). The overall switch rate was 6.3% for patients treated with tranylcypromine and 18.4% for patients in the control group.

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Drug hypersensitivity syndrome is among the most severe drug hypersensitivity reactions and in rare cases it may progress to hemophagocytic lymphohistiocytosis. Herein, we report a case of allopurinol-induced drug reaction with eosinophilia and systemic symptoms complicated by hemophagocytic lymphohistiocytosis.

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Neurology service, inpatient hospitalization, and outpatient follow-up in a neurology clinic.

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The objective of this article is to assess whether SUNCT is a subset of SUNA or whether the two are separate syndromes and clarify the role of neurovascular compression.

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Dravet syndrome is a highly pharmaco-resistant form of epilepsy. Valproate and benzodiazepines are the first-line treatment but are usually insufficient therapeutic options. Lamotrigine, carbamazepine and high doses of intravenous phenobarbital can aggravate seizures and should be avoided. Topiramate, levetiracetam, bromide and ketogenic diet also provide substantial efficacy as adjunctive therapy and procedures. Stiripentol is the only new drug to demonstrate efficacy when combined with valproate and clobazam, as shown in two independent double-blind controlled trials dedicated to Dravet children. In order to avoid side effects (mainly loss of appetite and loss of weight) resulting from the inhibition of cytochromes P450 by stiripentol, the prescribed doses of valproate and clobazam should be reduced. Stiripentol has a proper antiepileptic effect and enhances GABAergic neurotransmission by acting on the alpha-3 subunit of GABA(A) receptors. Stiripentol was approved as an orphan drug in Europe in 2007 for adjunctive therapy in Dravet syndrome. More than 500 Dravet patients have currently been satisfactorily treated and recent experiments in Japan have confirmed stiripentol's benefit. In practice, valproate should be initiated at the first onset of complicated febrile seizure in Dravet patients. Relapses justify the addition of clobazam and stiripentol when available. Topiramate and a ketogenic diet are alternatives in pharmaco-resistant cases.

lamictal overdose

Tolerability and safety are important considerations in optimising pharmacotherapy for bipolar disorder. This paper reviews the tolerability and safety of lamotrigine, an anticonvulsant recommended in the 2002 American Psychiatric Association guidelines as a first-line treatment for acute depression in bipolar disorder and one of several options for maintenance therapy. This paper reviews the tolerability and safety of lamotrigine using data available from a large programme of eight placebo-controlled clinical trials of lamotrigine enrolling a total of nearly 1800 patients with bipolar disorder. This review is the first to collate all the safety information from these clinical trials, including data from four unpublished studies. The results these trials in which 827 patients with bipolar disorder were given lamotrigine as monotherapy or adjunctive therapy for up to 18 months for a total of 280 patient-years of exposure demonstrated that lamotrigine is well-tolerated with an adverse-event profile generally comparable with that of placebo. The most common adverse event with lamotrigine was headache. Lamotrigine did not appear to destabilise mood and was not associated with sexual adverse effects, weight gain, or withdrawal symptoms. Few patients experienced serious adverse events with lamotrigine, and the incidence of withdrawals because of adverse events was low. Serious rash occurred rarely (0.1% incidence) in the clinical development programme including both controlled and uncontrolled clinical trials. These findings - considered in the context of data showing lamotrigine to be effective for bipolar depression - establish lamotrigine as a well-tolerated addition to the psychotropic armamentarium.

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To analyze the cost of monotherapeutic treatment of patients with newly diagnosed epilepsy.

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Reductions in LTG serum levels are a relevant contributing factor for early postoperative seizures. Postoperative alteration of the gastrointestinal motility and transient time leading to delayed absorption and reduced bioavailability of AED may be a major risk factor. Therefore, close monitoring of postoperative LTG serum levels is necessary and should lead to a temporary dose augmentation and/or anticonvulsant co-medication with benzodiazepines in case of a pronounced reduction of serum levels.

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lamictal increased dosage 2017-02-12

La syndrome de Stevens-Johnson (SJS) et la nécrolyse épidermique toxique sont des maladies dans le spectre de réactions cutanées graves affectant la peau et les muqueuses. Les médicaments antiépileptiques sont utilisés en combinaison, et ceci peut provoquer des effets indésirables. Ici, nous rapportons un cas rare de SJS déclenché par une combinaison de clobazam, la lamotrigine et l’acide valproïque chez un garçon de 7 ans. En raison de l’ insuffisante maîtrise des crises, le lorazépam a été utilisé avec le clobazam. Quatre semaines après l’ajout de clobazam, le patient a développé SJS avec une éruption cutanée généralisée, de la fièvre. Il y avait la participation de la foie et les reins, et une éosinophilie, une semaine après le début du traitement. Tous les médicaments antiépileptiques ont été abandonnées, et la méthylprednisolone intraveineuse, des antibiotiques systémiques prophylactiques, supplément de liquide par voie intraveineuse, antipyrétique, les soins des plaies spécial, et de soutien pour les soins médicaux ont été administrés. Il a été libéré dans un état stable la 18ème journée. Notre cas suggère qu’une interaction médicamenteuse entre le valproate, la lamotrigine et clobazam ait contribué au développement de SJS. Lorsque le clobazam a été ajouté à l’acide valproïque et la Himplasia Tablets lamotrigine, la dose de lamotrigine aurait dû être diminué.

lamictal user reviews 2016-02-29

In patients taking Lipitor Went Generic antiepileptic drugs (AEDs) for epilepsy, adverse effects (AEs) often lead to unfavorable quality of life, impaired adherence, and, eventually, discontinuation of pharmacological treatment. In a true-to-life sample of subjects from our academic epilepsy outpatient clinic, we aimed to identify predictors for overall high AE burden and for specific AEs focusing on patients on monotherapy.

lamictal dosage forms 2015-01-03

Subjects were randomized to receive either lamotrigine titrated on days 1-42 with olanzapine added on days 43-56 ( Lipitor Medication LTG + OLZ group; N = 16), lamotrigine titration with placebo added on days 43-56 (LTG group; N = 12), or placebo on days 1-42 with olanzapine added on days 43-56 (OLZ group; N = 16). Steady state (0-24 h) pharmacokinetic profiles were determined on day 56 in each group.

lamictal 800 mg 2017-11-02

The recent literature on the economic aspects of epilepsy and antiepileptic treatment are systematically reviewed. Studies for this literature review were selected by conducting a Medline literature search from January 1998 to October 2004. Studies reviewed had to follow one of the standard methods of health economics evaluation (cost of illness, cost-minimization analysis, cost-effectiveness analysis, cost-benefit analysis and cost-utility analysis). A total of 31 epilepsy cost studies were reviewed. Cost-of-illness studies showed a marked difference in cost between countries and healthcare systems. Cost-minimization analysis evaluations of four drugs with equivalent clinical efficacy found lamotrigine to be the most costly and carbamazepine the most economic. Cost-effectiveness analysis studies found topiramate to be more cost effective than lamotrigine, and surgical lobectomy to be a very cost-effective treatment in the long term. Cost-benefit analysis studies generally focused on vagal nerve stimulation and epilepsy surgery, and found both treatment modalities to be significantly cost beneficial. Only two cost-utility analysis studies were performed and found long-term lamotrigine treatment to be less economically effective than most other pharmacologic treatments of serious disorders. Vagal nerve stimulation was found to be of questionable economic value and further research is necessary for clarification. The methodologic heterogeneity observed in the studies reviewed makes comparisons between them difficult. Nevertheless, many interesting interpretations arise from the results. Cost-effectiveness analysis studies were found to be much more credible than cost-minimization or cost-benefit analysis evaluations since they avoid efficacy of drugs being reduced to clinical efficacy parameters alone. Cost-utility analysis studies were found to be the most promising type of economic analysis since they are the only type of analysis that incorporates the patients' point of view. In conclusion, comparison across studies can only be achieved if future studies follow a common set of methods and similar economic-evaluation models. A collaborative effort of all experts involved is necessary if this is to be achieved. Naprosyn 600 Mg

lamictal dosage pediatric 2017-11-25

A total of 2703 patients newly diagnosed with bipolar disorder were enrolled. The ratio of good adherence, defined as Evecare Himalaya Drugs medications possession ratio greater than 0.8, for use of the examined psychopharmacological medication was relatively low during the study period. The use of first-generation APs, selective serotonin reuptake inhibitors, tricyclic antidepressants, lithium, carbamazepine, and benzodiazepines has declined; however, the use of second-generation APs, serotonin and norepinephrine reuptake inhibitors, lamotrigine, and valproate has risen markedly during the 10-year period.

lamictal normal dosage 2015-09-16

To synthesise the evidence for the efficacy of lamotrigine in bipolar depressive Augmentin 200 Mg episodes.

700 mg lamictal 2016-10-08

A highly specific and sensitive multiplex SRM-MS assay was established for development and verification of CSF protein biomarkers in SPMS. Five proteins were found to be expressed significantly differently between the three cohorts, SPMS, NIND and HC and 11 proteins associated with lamotrigine treatment, which we expect Amalaki Drug Interactions will further our current understanding of SPMS disease pathology and/or therapeutic intervention.

lamictal drug interactions 2017-10-25

As human neurobiological phenomena, laughter and humour also belong to the field of clinical neurology; their processing is affected in a number of different diseases and, in certain cases, Epivir Dosage Forms effective treatment can be established.

lamictal 50mg tablet 2016-10-29

This study is a literature review Cardura Maximum Dose with analysis.

lamictal dosage 2016-07-05

Women with Cleocin Elixir Dosage epilepsy (WWE) tend to have hormonal and metabolic abnormalities, raising concerns about an increased risk of cardiovascular disorders. This study was performed to determine whether epilepsy itself and/or antiepileptic drug (AED) medication cause metabolic abnormalities.