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Ventolin

Ventolin is a high-effective medication which is indicated for the relief and prevention of airway obstruction (bronchospasm) in patients with asthma and in patients with exercise-induced asthma. Ventolin can also be used in treating patients with emphysema and chronic bronchitis when their symptoms are related to reversible airway obstruction.

Other names for this medication:
Airet, Airomir, Apo-salvent, Assal, Asthalin, Aurosal, Avedox-fc, Broncovaleas, Ecutamol, Farbutamol, Novo-salmol, Salamol, Salbubronch, Salbutalan, Salbutamol, Salvent, Sultanol, Ventide, Ventodisk, Ventorlin, Volmax

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Also known as:  Albuterol.

Description

Ventolin belongs to a class of drugs known as bronchodilators. Ventolin is indicated for the relief and prevention of airway obstruction (bronchospasm) in patients with asthma and in patients with exercise-induced asthma. Ventolin can also be used in treating patients with emphysema and chronic bronchitis when their symptoms are related to reversible airway obstruction.

Albuterol, the active ingredient in Ventolin is a selective beta-adrenergic bronchodilator used to treat severe acute asthma and chronic bronchospasm caused by other pulmonary obstructive disorders that have not responded to other forms of therapy.

Generic names of Ventolin are Albuterol, Salbutamol.

Ventolin is also known as Albuterol, Salbutamol, Ventorlin, Asthalin, Proventil, ProAir, Salamol, Aerolin.

Dosage

Follow the directions for using this medicine provided by your doctor. Use Ventolin exactly as directed.

Take this medication by mouth as directed by your doctor.

Do not crush or chew it. Swallow the pill whole. Crushing or chewing Ventolin will negate the delayed release mechanism of the medication.

-The usual effective dose is 4mg, three or four times per day.

-If adequate bronchodilation is not obtained, each single dose may be gradually increased to as much as 8mg.

-Some patients obtain adequate relief with 2 mg three or four times daily.

2 - 6 years: The minimum starting dose is 1mg three times daily. This may be increased to 2mg (1 tablet), three or four times daily.

6 - 12 years: The minimum starting dose is 2mg three times daily. This may be increased to four times daily.

Over 12 years: The minimum starting dose is 2mg three times daily. This may be increased to 4mg (2 tablets), three or four times daily.

In elderly patients or in those known to be usually sensitive to beta-adrenergic stimulant drugs, it is advisable to initiate treatment with 2 mg salbutamol three or four times per day.

Overdose

If you overdose Ventolin and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at a room temperature not exceeding 30 degrees C (86 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Ventolin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Ventolin if you are allergic to Ventolin components.

It is not known whether Ventolin will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant or breast-feeding.

Be careful with Ventolin if you have diabetes, heart disease, high blood pressure (hypertension), hyperthyroidism, irregular heart beats (arrhythmias).

Ventolin may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.

Do not stop treatment, even if you are feeling better, unless your doctor tells you to. It may take 2 weeks or longer before you feel the full benefit of the medication.

Avoid alcohol.

Do not stop taking Ventolin suddenly.

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The goal of the present study was to identify airway and alveolar site(s) of inflammation using exhaled nitric oxide (NO) as a marker in asthmatic patients, and to evaluate the NO response to maintenance fluticasone 250 microg/salmeterol 50 microg (F/S) and add-on montelukast 10 mg (M).

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Spirometry is an important component of the National Asthma Education and Prevention Program guidelines for asthma, yet published data show variable associations between forced expiratory volume in 1 second percentage (FEV1%) predicted, symptoms and health care utilization. The objective of this analysis was to examine the association between FEV1% and future risk of exacerbations among a well-characterized population of children with asthma.

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In this 8-week study, subjects with moderate to severe COPD experienced greater improvements in lung function and symptom measures with FSC than with IB/ALB.

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The mass median diameter (MMD) for the tgAAVCF was 2.78 +/- 0.43 microm. If the system works ideally and the patient only receives aerosol on inspiration, the patient would receive 47 +/- 0% of the initial dose placed in the nebulizer, with 72 +/- 0.73% of this being deposited beyond the vocal cords.

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Twenty patients took part in the trial. Compared with the placebo, the inhalation of salmeterol significantly increased the FEV(1). Even in the 9 patients treated with high-dose ICSs plus theophylline plus a leukotriene receptor antagonist, the FEV(1) increased significantly more after salmeterol than after the placebo.

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The objective of the article was to perform a predictive analysis, based on quantitative structure-property relationships, of the dissociation constants (pK(a)) of different medicinal compounds (e.g., salicylic acid, salbutamol, lidocaine). Given the importance of this property in medicinal chemistry, it is of interest to develop theoretical methods for its prediction. The descriptors selection from a pool containing more than a thousand geometrical, topological, quantum-mechanical, and electronic types of descriptors was performed using the enhanced replacement method. Genetic algorithm and the replacement method (RM) techniques were used as reference points. A new methodology for the selection of the optimal number of descriptors to include in a model was presented and successfully used, showing that the best model should contain four descriptors. The best quantitative structure-property relationships linear model constructed using 62 molecular structures not previously used in this type of quantitative structure-property study showed good predictive attributes. The root mean squared error of the 26 molecules test set was 0.5600. The analysis of the quantitative structure-property relationships model suggests that the dissociation constants depend significantly on the number of acceptor atoms for H-bonds and on the number of carboxylic acids present in the molecules.

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This paper describes a series of stability and redistribution studies aimed at understanding the presence and significance of beta 2-agonists in asthma deaths. Salbutamol and terbutaline were shown to be stable in postmortem blood at 23 degrees C for 1 week, 4 degrees C for 6 months and -20 degrees C for 1 to 2 years. However, fenoterol was shown to degrade at 23 degrees C (83% loss), 4 degrees C (93% loss) and -20 degrees C (66% loss) over the same time. Salbutamol concentrations detected in blood taken at the time of body admission to the mortuary were not significantly different from the concentrations detected in blood taken from the same cases at the time of autopsy (45 h later). This suggests that significant postmortem redistribution of salbutamol is unlikely to occur during this period. Postmortem blood concentrations of at least salbutamol are likely to reflect the concentration of these drugs in the body at the time of death.

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Sensitivity and exposure to indoor allergens constitutes a risk factor for the development and persistence of asthma in children.

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We measured the uptake of the soluble inert gas dimethyl ether (DME) from a segment of the conducting airways to estimate mucosal blood flow (Qaw) noninvasively. The subjects inhaled, from the functional residual capacity position, a 300-ml gas mixture containing 35% DME, 8% helium, 35% oxygen, and the balance nitrogen; they held their breath for 5 s and then exhaled into a spirometer. During exhalation, the instantaneous concentrations of DME and helium were recorded together with expired gas volume. The maneuver was repeated with breathhold times of 5, 10, 15, and 20 s. We calculated Qaw using the time-dependent decrease in DME concentration in relation to the helium concentration in an expired volume fraction between 80 and 130 ml (representing an anatomic dead-space segment distal to the glottis) and the mean DME concentration. In 10 healthy nonsmokers, mean (+/- SE) Qaw was 8.0 +/- 1.3 ml/min, or 8 +/- 2 microliters/min/cm2 mucosal surface. We obtained a value of 12 +/- 3 microliters/min/cm2 in a validation experiment in sheep. Inhaled methoxamine (nebulized dose 10 mg) caused a 65 +/- 19% decrease (p < 0.05), and albuterol (nebulized dose 2.5 mg) a 92 +/- 17% increase (p < 0.05), in mean Qaw in seven subjects, with the maximum changes occurring immediately or 15 min postinhalation. We conclude that the DME uptake method is an acceptable noninvasive means of estimating airway mucosal blood flow in humans and its modification by vasoactive substances.

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ventolin inhaler cheap 2015-08-12

This article is based on a study first published in Allergy. The bronchodilating effect of the long acting beta 2-agonist formoterol dey powder (dp) 12 micrograms twice daily was compared to salbutamol 400 micrograms four times daily and placebo in patients with reversible obstructive airway disease. The study design consisted of a closed Voltaren 50mg Generic 12-week double-blind, placebo-controlled, multicentre trial followed by an open noncomparative, multicentre 12-month follow-up trial, in which tolerability of formoterol dp was assessed. A total of 304 patients aged 18-79 years were randomized. The bronchodilating effect of formoterol, assessed by morning premedication peak flow rate, was significantly superior to placebo (p < 0.0001) and salbutamol (p < 0.001). Efficacy was maintained during the open follow-up study. Formoterol 12 micrograms twice daily significantly reduced morning and evening asthma symptoms and sleep disturbances, and significantly reduced the need for rescue medication. In conclusion, formoterol 12 micrograms dp twice daily was significantly superior to both salbutamol 400 micrograms dp four times daily and placebo, and reduced asthma symptoms significantly. Overall, formoterol showed a tolerability profile comparable to that of salbutamol, and no tachyphylaxis was observed during one year of treatment.

ventolin daily dose 2015-09-15

Salbutamol sulphate nanoparticles have been simultaneously prepared and coated with L-leucine in the gas phase. Three different ways of coating can be separated based on the operation temperatures used in an aerosol flow reactor. Below the temperature of L-leucine sublimation, formation of the L-leucine layer on the core particle surface takes place via diffusion of L-leucine molecules on the droplet surfaces during droplet drying. At intermediate temperatures, the extent of sublimation of L-leucine depends notably on the concentration, and thus partial evaporation was expected. The L-leucine coating was solely formed via vapor deposition at high reactor temperatures when complete sublimation of L-leucine was obtained. The geometric mean diameter of the core salbutamol particles was approximately 65 nm. In general, particle size increased with the addition of L-leucine. The size distribution remained the same or broadened when the coating layer of the particles was formed via surface diffusion whereas notable narrowing of the distribution was observed when the coating was formed via vapor deposition. Upon desublimation and heterogeneous nucleation on the surfaces of smooth, spherical core particles, L-leucine formed a discontinuous Luvox Cr Reviews coating with leafy crystals a few nanometers in size.

ventolin dose counter 2015-01-27

We detected significant improvement in pulmonary function studies over 120 minutes Prevacid Dosage Pediatrics in children with severe asthma who were given nebulized ipratropium combined with albuterol and oral steroids, compared with children who received the standard therapy. Further study is needed to determine whether early use of ipratropium decreases the need for hospitalization.

ventolin nebulizer dose 2015-05-19

Separate randomized, double-blind, parallel-arm, placebo-controlled trials compared two administrations of inhaled loxapine (10 mg) 10 hr apart with placebo in 52 subjects with asthma and in 53 subjects with COPD. A thermally-generated drug aerosol of loxapine was delivered to the deep lung Alprostadil Online Prescription for rapid systemic absorption. Controller medications were continued throughout the study, but quick-relief bronchodilators were withheld from 6-8 hr before through 34 hr after dose 1, unless indicated as rescue.

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Data from all trials were combined using the Review Bactrim 960 Mg Manager (version 4.1). We planned to perform: 1) random effects weighted mean difference (WMD), with 95% confidence intervals (95% CI), 2) Homogeneity of effect sizes with the Dersimonian and Laird method with p<0.1 as the cut point for significance, and 3) sensitivity analysis on different helium-oxygen mixtures (80/20 vs 70/30), and 4) methodological quality (Jadad score >2 vs. <3).

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Sixty-seven studies (representing 68 experimental comparisons) randomising 42,333 participants met the inclusion criteria. Salmeterol was used as long-acting agent in 50 studies and formoterol fumarate in 17. The treatment period was four to nine weeks in 29 studies, and 12 to 52 weeks in 38 studies. Twenty-four studies did not permit the use of ICS, and forty permitted either inhaled corticosteroid or cromones (in three studies this was unclear). In these studies between 22% and 92% were taking ICS, with a median of 62%. There were significant advantages to LABA treatment compared to placebo for a variety of measurements of airway calibre including morning peak expiratory flow (PEF), evening PEF and FEV1. They were associated with significantly fewer symptoms, less use of rescue medication and higher quality of life scores. This was true whether patients were taking LABA in combination with ICS or not. Findings from SMART (a recently published surveillance study) indicated significant increases in asthma related deaths, respiratory related deaths and combined asthma related deaths and life threatening Trileptal 2400 Mg experiences. The absolute increase in asthma-related mortality was consistent with an increase of around one per 1250 patients treated with LABA for six months, but the confidence intervals are wide (from 700 to 10,000). Post-hoc exploratory subgroups suggested that African-Americans and those not on inhaled corticosteroids were at particular risk for the primary end-point of death or life-threatening asthma event. There was also a suggestion of an increase in exacerbation rate in children. Pharmacologically predicted side effects such as headache, throat irritation, tremor and nervousness were more frequent with LABA treatment.

ventolin expectorant dosage 2015-06-12

150 children 5-14 yr of age with persistent asthma presenting with peak expiratory flow (PEF) < 70% of personal best were randomized Artane Pill Sizes to receive 200 mg salbutamol through one of five spacers: A) 750 ml spacer with valve, B) 165 ml spacer with valve, C) 250 ml spacer without valve, D) 1000 ml indigenously made spacer without valve and E) 500 ml indigenously made spacer without valve. PEF measurement was repeated 15 minutes later. Children> 8 yr old performed spirometry in addition to PEF. Absolute change and percentage improvement of PEF and FEV1 were compared among the groups.

ventolin generic name 2015-02-05

The effect of inhaler orientation at the inhaler-mouth interface on MT aerosol deposition appeared Eldepryl And Alcohol to be dependent on velocity, aerosol size, and formulation. These findings not only demonstrate the need for patient education on correct inhaler orientation, but provide important new methods for those designing new inhalers.

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This study was commenced before mandatory registration of clinical trials.

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At unequal ratios of mannitol to lactose, the elongated shape dominated in the crystallisation process. However, lactose exerted an opposite effect to that of mannitol by reducing elongation ratio and increasing the crystals' width and thickness. Crystallised β-lactose showed different anomers compared to commercial lactose (α-lactose monohydrate). Crystallised α-mannitol showed different polymorphic form compared to commercial mannitol (β-mannitol). Crystallised mannitol:lactose showed up to 5 transitions corresponding to α-mannitol, α-lactose monohydrate, β-lactose, 5α-/3β-lactose and 4α-/1β-lactose. In vitro deposition assessments showed that crystallised carriers produced more efficient delivery of salbutamol sulphate compared to formulations containing commercial grade carriers.

ventolin drug interactions 2015-01-04

In slow-channel congenital myasthenic syndrome, point mutations of the endplate acetylcholine receptor (AChR) prolong channel openings, leading to excessive Ca(2+) entry with ensuing endplate degeneration and myasthenic symptoms. The Ca(2+) permeability of the human endplate AChR-channel is quite high, and is further increased by two slow-channel mutations in its ɛ subunit, worsening the pathological cascade. To gain further support to the hypothesis that the ɛ subunit plays a crucial role in controlling Ca(2+) permeability of endplate AChR-channel, in this work we measured the fractional Ca(2+) current (P(f), i.e., the percentage of the total current carried by Ca(2+) ions) of a panel of AChR carrying slow-channel mutations in the α, β and ɛ subunits detected in patients (α(N217K), α(S226Y), α(C418W), β(V266A), β(V266M), ɛ(I257F), ɛ(V265A) and ɛ(L269F)). We confirm that only mutations in the ɛ subunit altered Ca(2+) permeability of AChR-channels, with ɛ(L269F) increasing P(f) (10% vs. 7% of wild type AChR) and ɛ(I257F) decreasing it (to 4.6%). We also found that, for ɛ(L269F)-AChR, the Ca(2+) permeability and ACh-induced cell death can be normalized by clinically relevant concentrations of salbutamol or verapamil, providing the first evidence that the Ca(2+) permeability of AChR-channels can be modulated and this treatment may provide protection against excitotoxic insults.